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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
49.39
Human Site:
T642
Identified Species:
72.44
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
T642
G
R
Y
D
P
S
L
T
F
S
E
N
V
D
L
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
T633
G
R
Y
D
P
S
L
T
F
S
E
N
V
D
L
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
I616
I
S
I
S
K
A
G
I
V
T
S
L
Q
A
R
Dog
Lupus familis
XP_541736
1001
113024
T740
G
R
Y
D
P
S
L
T
F
S
D
N
V
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
T642
G
R
Y
D
P
S
L
T
F
S
E
N
V
D
L
Rat
Rattus norvegicus
NP_001101343
905
102125
T643
G
R
Y
D
P
S
L
T
F
S
E
N
V
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
T649
G
R
Y
D
P
S
L
T
F
S
E
N
V
D
L
Chicken
Gallus gallus
NP_001006139
888
100332
T629
G
R
Y
D
P
S
L
T
F
L
E
N
V
D
L
Frog
Xenopus laevis
P55861
886
100243
T627
G
R
Y
D
P
S
L
T
F
S
E
N
V
D
L
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
T621
G
R
Y
D
P
S
L
T
F
S
E
N
V
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
T627
G
R
Y
D
P
S
M
T
F
S
E
N
V
N
L
Honey Bee
Apis mellifera
XP_395109
1005
114136
T746
G
R
Y
D
A
S
M
T
F
S
E
N
V
D
L
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
D524
Y
I
V
K
D
T
H
D
V
L
K
D
A
T
L
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
T627
G
R
Y
N
P
S
L
T
F
S
E
N
V
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
Y533
N
A
A
I
F
V
K
Y
D
R
M
L
H
G
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
I629
E
A
M
E
Q
Q
S
I
S
I
S
K
A
G
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
100
0
93.3
N.A.
100
100
N.A.
100
93.3
100
100
N.A.
86.6
86.6
6.6
93.3
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
100
93.3
100
100
N.A.
100
93.3
26.6
100
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
0
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
7
0
7
7
0
0
0
0
0
0
13
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
69
7
0
0
7
7
0
7
7
0
69
0
% D
% Glu:
7
0
0
7
0
0
0
0
0
0
69
0
0
0
0
% E
% Phe:
0
0
0
0
7
0
0
0
75
0
0
0
0
0
0
% F
% Gly:
75
0
0
0
0
0
7
0
0
0
0
0
0
13
0
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% H
% Ile:
7
7
7
7
0
0
0
13
0
7
0
0
0
0
7
% I
% Lys:
0
0
0
7
7
0
7
0
0
0
7
7
0
0
0
% K
% Leu:
0
0
0
0
0
0
63
0
0
13
0
13
0
0
82
% L
% Met:
0
0
7
0
0
0
13
0
0
0
7
0
0
0
0
% M
% Asn:
7
0
0
7
0
0
0
0
0
0
0
75
0
7
0
% N
% Pro:
0
0
0
0
69
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
7
7
0
0
0
0
0
0
7
0
7
% Q
% Arg:
0
75
0
0
0
0
0
0
0
7
0
0
0
0
7
% R
% Ser:
0
7
0
7
0
75
7
0
7
69
13
0
0
0
0
% S
% Thr:
0
0
0
0
0
7
0
75
0
7
0
0
0
7
0
% T
% Val:
0
0
7
0
0
7
0
0
13
0
0
0
75
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
75
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _